The development of the central nervous system (CNS) is governed by networks of extrinsic
and intrinsic molecular programs that together orchestrate precise gene regulation. For the …

Healthy lifestyles and environment produce a good state of health. A number of scientific
studies support the notion that external stimuli regulate an individual′ s epigenomic profile …

Stem cells represent one of the most promising areas in biological and medical research. All
stem cells are defined as having two basic properties: unlimited self-renewal and the broad …

The “chromogenome” is defined as the structural and functional status of the genome at any
given moment within a eukaryotic cell. This article focuses on recently uncovered …

Background Gene activation is thought to occur through a series of temporally defined
regulatory steps. However, this process has not been completely evaluated in single living …

Eukaryotic genomic DNA is orderly compacted to fit into the nucleus and to inhibit
accessibility of specific sequences. DNA is manipulated in many different ways by bound …

The lineage-specifying factor Th-inducing POK (ThPOK) directs the intrathymic
differentiation of CD4 T cells. Although the regulation of ThPOK at the transcription level has …

We previously reported genome-wide evidence that the Gcn5 histone acetyltransferase
(HAT) is located in the transcribed region of highly expressed genes and that it plays an …

Embryonic stem cells (ESC) have the potential to self-renew indefinitely and to differentiate
into any of the three germ layers. The molecular mechanisms for self-renewal, maintenance …

Gene transcription is largely regulated by DNA-binding transcription factors (TFs). However,
the TF activity itself is modulated via, among other things, post-translational modifications …