Histone acetyltransferases (HATs) are enzymes able to acetylate lysine side chains of
histones. They play essential roles in normal cell function as well as in pathogenesis of a …

In higher eukaryotes, histone acetyltransferase MOF (male absent on the first) is the major
enzyme that acetylates histone H4 lysine 16, a prevalent mark associated with chromatin …

Histone acetylation is a key modification that regulates chromatin accessibility. Here we
show that treatment with butyrate or other histone deacetylase (HDAC) inhibitors does not …

Methylation and acetylation of lysines are crucial posttranslational modifications that
regulate gene transcription and have been shown to be misregulated in many forms of …

Bruton's tyrosine kinase (Btk) is essential for BCR signal transduction and has diverse
functions in B cells. Although Btk has been extensively studied, the role of lysine acetylation …

Epigenetic regulation refers to the mechanisms that alter gene expression patterns in the
absence of changes in the nucleotide sequence of the DNA molecule. The EHVW …

Ecdysoneless (Ecd) is an evolutionarily conserved protein and its function is essential for
embryonic development in Drosophila and cell growth in yeast. However, its function has …

We report the results of a chemogenomic profiling aimed to explore the mode of action of a
quinolic analogue of the p300 histone acetyltransferase (HAT) inhibitor anacardic acid …

The invention provides the use of certain benzoic acid and benzamide compounds as
modulators of enzymes histone acetyltransferases, which are involved in gene expression …

Epigenetic mechanisms, namely histone modifications and DNA methylation induced
changes in the chromatin, give rise to epigenomes, which add diversity and complexity to …