SIRT1 is the closest mammalian homologue of enzymes that extend life in lower organisms.
Its role in mammals is incompletely understood, but includes modulation of at least 34 …

The budding yeast nucleus, like those of other eukaryotic species, is highly organized with
respect to both chromosomal sequences and enzymatic activities. At the nuclear periphery …

Sirtuins (silent information regulator 2 [Sir2] proteins) belong to an ancient family of
evolutionary conserved nicotinamide adenine dinucleotide (NAD)+-dependent enzymes …

The monopolin complex regulates different types of kinetochore-microtubule attachments in
fungi, ensuring sister chromatid co-orientation in Saccharomyces cerevisiae meiosis I and …

The endoplasmic reticulum (ER) plays an essential role in the production of lipids and
secretory proteins. Because the ER cannot be generated de novo, it must be faithfully …

The study of genomic organization and regulatory elements of rRNA genes in metazoan
paradigmatic organisms has led to the most accepted model of rRNA gene organization in …

The way in which the number and size of cells in an organ are determined poses a central
challenge in our understanding of organ size control. Compensation is an unresolved …

Molecular studies in model organisms have identified potent longevity genes which can
delay the aging process and extend the lifespan. Longevity factors promote stress resistance …

The Sir2 family proteins (sirtuins) are evolutionally conserved NAD+ (nicotinamide adenine
dinucleotide)-dependent protein deacetylases and ADP-ribosylases, which have been …

The mitochondrial retrograde response has been extensively described in Saccharomyces
cerevisiae, where it has been found to extend life span during times of mitochondrial …