Sir2-dependent daughter-to-mother transport of the damaged proteins in yeast is required to prevent high stress sensitivity of the daughters
DA Knorre, IA Kulemzina, MI Sorokin, SA Kochmak… - Cell Cycle, 2010 - Taylor & Francis
The budding yeast Saccharomyces cerevisiae actively transports adverse factors (eg
oxidized proteins) from the daughter to mother cells. The transport is believed to ensure that …
oxidized proteins) from the daughter to mother cells. The transport is believed to ensure that …
Comparative analyses of time-course gene expression profiles of the long-lived sch9Δ mutant
In an attempt to elucidate the underlying longevity-promoting mechanisms of mutants
lacking SCH9, which live three times as long as wild type chronologically, we measured …
lacking SCH9, which live three times as long as wild type chronologically, we measured …
DNA ligase 4 stabilizes the ribosomal DNA array upon fork collapse at the replication fork barrier
O Fritsch, MD Burkhalter, S Kais, JM Sogo, P Schär - DNA repair, 2010 - Elsevier
DNA double-strand breaks (DSB) were shown to occur at the replication fork barrier in the
ribosomal DNA of Saccharomyces cerevisiae using 2D-gel electrophoresis. Their origin …
ribosomal DNA of Saccharomyces cerevisiae using 2D-gel electrophoresis. Their origin …
[HTML][HTML] Sir2-dependent asymmetric segregation of damaged proteins in ubp10 null mutants is independent of genomic silencing
Carbonylation of proteins is an irreversible oxidative damage that increases during both
chronological and replicative yeast aging. In the latter, a spatial protein quality control …
chronological and replicative yeast aging. In the latter, a spatial protein quality control …
Perspectives on the mitochondrial etiology of replicative aging in yeast
A Ugidos, T Nyström, A Caballero - Experimental gerontology, 2010 - Elsevier
In a now classical paper, Denham Harman suggested that free radicals produced during
mitochondrial respiration cause cumulative oxidative damage, resulting in aging and age …
mitochondrial respiration cause cumulative oxidative damage, resulting in aging and age …
Yin and Yang of histone H2B roles in silencing and longevity: a tale of two arginines
In budding yeast, silent chromatin is defined at the region of telomeres, rDNA loci, and silent
mating loci. Although the silent chromatin at different loci shows structural similarity, the …
mating loci. Although the silent chromatin at different loci shows structural similarity, the …
Modeling growth and telomere dynamics in Saccharomyces cerevisiae
P Olofsson, AA Bertuch - Journal of theoretical biology, 2010 - Elsevier
A general branching process is proposed to model a population of cells of the yeast
Saccharomyces cerevisiae following loss of telomerase. Previously published experimental …
Saccharomyces cerevisiae following loss of telomerase. Previously published experimental …
Methods for extending the replicative lifespan of cells
US7838503B2 - Methods for extending the replicative lifespan of cells - Google Patents
US7838503B2 - Methods for extending the replicative lifespan of cells - Google Patents Methods …
US7838503B2 - Methods for extending the replicative lifespan of cells - Google Patents Methods …
Sirt1's beneficial roles in neurodegenerative diseases–a chaperonin containing TCP‐1 (CCT) connection?
BQ Gan, BL Tang - Aging Cell, 2010 - Wiley Online Library
Sir2/Sirt1 and its orthologues are known lifespan extension factors in several aging models
from yeast to invertebrates. Sirt1 activation is also known to be beneficial and protective in …
from yeast to invertebrates. Sirt1 activation is also known to be beneficial and protective in …
Calorie restriction mimetics and aging
BJ Morris - Calorie Restriction, Aging and Longevity, 2010 - Springer
Various polyphenols found in plants are able to activate biochemical pathways in
mammalian cells so as to confer health benefits. These molecules include resveratrol …
mammalian cells so as to confer health benefits. These molecules include resveratrol …