This initial chapter introduces those that follow with a summary of the life spans and end of
life pathologies of the several species that are included in later chapters. It is not presented …

Propagation of a species requires periodic cell renewal to avoid clonal senescence. Liu et
al.(2010) now describe a new mechanism of cell renewal in budding yeast, in which …

Aging is a complex biological process that manifests through cellular, physical, and
metabolic changes in all types of tissues. Changes in chromosome structure and function …

Chromatin is the template of all processes involved in DNA metabolism in the eukaryotic
cell. Accordingly, chromatin is a dynamic structure which changes in its composition and …

Sirtuins are a family of highly conserved genes widely distributed in organisms ranging from
bacteria to humans. Mounting evidence has revealed the important role of sirtuins in a …

Healthy lifestyles and environment produce a good state of health. A number of scientific
studies support the notion that external stimuli regulate an individual's epigenomic profile …

Stres oksydacyjny jako uniwersalna przyczyna starzenia się – od somatycznych komórek
człowieka do jednokomórkowych drożdży i prokariotycznych komórek bakterii - Postępy …

Resumo da tese: Com o avançar da idade o organismo humano vai sofrendo um conjunto
de alterações que se vão acumulando, a este processo chama-se envelhecimento e o seu …

There has been expanding interest in research on aging and in the identification of
underlying mechanisms of the aging process. The promise that by understanding aging we …

The use of model organisms has provided great insight into the process of aging, particularly
during the last decade of research. Of the longevity factors identified, few have received …