2.1 Hintergrund Nach wie vor stellen Erkrankungen des kardiovaskulären Systems die
häufigste Todesursache der westlichen Nationen dar. Im Jahr 2007 erlag fast jeder zweite …

Background HMG‐CoA reductase inhibitors (statins) have antiatherogenic effects beyond
their cholesterol‐lowing effect. Whether atorvastatin has a stronger antioxidant effect than …

Of the 21 such patients involved in their study, 7 received fluvastatin 40 mg/day alone for 2
months and then in combination with valsartan 80 mg/day for 2 months (group A), 8 received …

In hypercholesterolemic and hypertensive patients, an increased propensity of their low-
density lipoprotein (LDL) to oxidative modification has been observed. Because oxidized …

Experimental and epidemiological studies indicate that the correlation between metabolic
disorders, oxidative stress and coronary artery disease (CAD) is continuous and graded …

Angiotensin II (Ang II) modulates vasomotor tone, cell growth, and extracellular matrix
deposition. This study analyzed the effect of atorvastatin in the possible alterations induced …

Angiotensin II is known to be a pro-inflammatory mediator, which causes an increase in
intracellular release of reactive oxygen species (ROS), which in turn causes impaired …

Aim of the study: To assess whether variations in antioxidant and anti-inflammatory
parameters occur with short term administration and discontinuation of atorvastatin in …

Statins are widely established as an important class of medications for primary and
secondary prevention of cardiovascular disease. In addition to their lipid-lowering effects …

Aim of the study was to investigate peculiarities of effects of rosuvastatin on the state of
oxidative stress and endogenous inflammation in patients with extensive atherosclerosis …