Yeast Sir2 deacetylase is a component of the silent information regulator (SIR) complex
encompassing Sir2/Sir3/Sir4. Sir2 is recruited to telomeres through Rap1, and this complex …

Saccharomyces cerevisiae Sir2 is an NAD+-dependent histone deacetylase that links
chromatin silencing to genomic stability, cellular metabolism and lifespan regulation. In …

In Saccharomyces cerevisiae, the repressive chromatin environment at telomeres gives rise
to telomere position effect (TPE), the epigenetic silencing of telomere-proximal genes …

The Sir2 deacetylase regulates chromatin silencing and lifespan in Saccharomyces
cerevisiae,. In mice, deficiency for the Sir2 family member SIRT6 leads to a shortened …

The Sir2 chromatin regulatory factor links maintenance of genomic stability to life span
extension in yeast. The mammalian Sir2 family member SIRT6 has been proposed to have …

The Sir2 histone deacetylase functions as a chromatin silencer to regulate recombination,
genomic stability, and aging in budding yeast. Seven mammalian Sir2 homologs have been …

Abstract The yeast Sir2/3/4p complex is found in abundance at telomeres, where it
participates in the formation of silent heterochromatin and telomere maintenance. Here, we …

SIRT1, the mammalian homolog of SIR2 in Saccharomyces cerevisiae, is an NAD-
dependent deacetylase implicated in regulation of lifespan. By designing effective short …

A general feature of the nucleus is the organization of repetitive deoxyribonucleic acid
sequences in clusters concentrating silencing factors. In budding yeast, we investigated how …

Genomic instability and alterations in gene expression are hallmarks of eukaryotic aging.
The yeast histone deacetylase Sir2 silences transcription and stabilizes repetitive DNA, but …