One of the many debated topics in ageing research is whether progeroid syndromes are
really accelerated forms of human ageing. The answer requires a better understanding of …

The Hutchinson–Gilford progeria syndrome (HGPS) is a premature aging disease caused by
mutations of the LMNA gene leading to increased production of a partially processed form of …

The molecular mechanisms involved in human aging are complicated. Two progeria
syndromes, Werner's syndrome (WS) and Hutchinson-Gilford progeria syndrome (HGPS) …

Products of the LMNA gene, primarily lamin A and C, are key components of the nuclear
lamina, a proteinaceous meshwork that underlies the inner nuclear membrane and is …

Hutchinson-Gilford progeria syndrome (HGPS) is a rare, fatal genetic disorder that is
characterized by segmental accelerated aging. The major causal mutation associated with …

Progeria: A Paradigm for Translational Medicine: Cell Skip to Main Content Advertisement Cell
This journal offers authors two options (open access or subscription) to publish research This …

Progeroid disorders make up a heterogeneous group of very rare hereditary diseases
characterized by clinical signs that often mimic physiological aging in a premature manner …

Ageing is a process that inevitably affects most living organisms and involves the
accumulation of macromolecular damage, genomic instability and loss of heterochromatin …

Ageing is the predominant risk factor for many common diseases. Human premature ageing
diseases are powerful model systems to identify and characterize cellular mechanisms that …

Progeroid syndromes are heritable human disorders displaying features that recall
premature ageing. In these syndromes, premature aging is defined as “segmental” since …