The new biology of ageing

L Partridge - … Transactions of the Royal Society B …, 2010 - royalsocietypublishing.org
Human life expectancy in developed countries has increased steadily for over 150 years,
through improvements in public health and lifestyle. More people are hence living long …

Understanding ageing

R Holliday - … Transactions of the Royal Society of …, 1997 - royalsocietypublishing.org
A broad biological approach makes it possible to understand why ageing exists and also
why different mammalian species have very different maximum logevities. The adult …

How genetic analysis tests theories of animal aging

S Hekimi - Nature genetics, 2006 - nature.com
Each animal species displays a specific life span, rate of aging and pattern of development
of age-dependent diseases. The genetic bases of these related features are being studied …

[图书][B] Understanding ageing

R Holliday - 1995 - books.google.com
This book presents a completely novel approach to the understanding of ageing, which
many believe is an unsolved problem in biology. It explains why ageing exists in animals …

Can aging be'drugged'?

CE Riera, A Dillin - Nature medicine, 2015 - nature.com
The engines that drive the complex process of aging are being identified by model-organism
research, thereby providing potential targets and rationale for drug studies. Several studies …

We need to shift the focus of aging research to aging itself

JR Poganik, VN Gladyshev - Proceedings of the National …, 2023 - National Acad Sciences
The field of aging is at a precipice. Attention and funding are increasingly focused on this
area, and exciting, fundamentally important findings are being reported literally every day …

Can we delay aging? The biology and science of aging

B Anton, L Vitetta, F Cortizo… - Annals of the New York …, 2005 - Wiley Online Library
Long before the fountain of youth, mankind has had an interest in staying young. As we
move into the 21st century, that interest has not only continued, but it has become an …

Horizons in the evolution of aging

T Flatt, L Partridge - BMC biology, 2018 - Springer
Between the 1930s and 50s, evolutionary biologists developed a successful theory of why
organisms age, firmly rooted in population genetic principles. By the 1980s the evolution of …

On the programmed/non-programmed nature of ageing within the life history

TBL Kirkwood, S Melov - Current Biology, 2011 - cell.com
Understanding why and how senescence evolved is of great importance in investigating the
multiple, complex mechanisms that influence the course of ageing in humans and other …

The genetics of aging

T Perls, L Kunkel, A Puca - Current opinion in genetics & development, 2002 - Elsevier
Once thought to be an extremely complex conundrum of weak genetic and environmental
effects, exceptional longevity is beginning to yield genetic findings. Numerous lower …