Genomes are organized into complex higher-order structures by folding of the DNA into
chromatin fibers, chromosome domains, and ultimately chromosomes. The higher-order …

Genomes have complex three-dimensional architectures. The recent convergence of
genetic, biochemical, biophysical, and cell biological methods has uncovered several …

Although the principles governing chromosomal architecture are largely unresolved, there is
evidence that higher-order chromatin folding is mediated by the anchoring of specific DNA …

Genomes exist in vivo as complex physical structures, and their functional output (ie the
gene expression profile of a cell) is related to their spatial organization inside the nucleus as …

The different cell types of an organism share the same DNA, but during cell differentiation
their genomes undergo diverse structural and organizational changes that affect gene …

Recent advances in molecular techniques and high-resolution imaging are beginning to
provide exciting insights into the higher order chromatin organization within the cell nucleus …

How chromosomes are organized within the tridimensional space of the nucleus and how
can this organization affect genome function have been long-standing questions on the path …

In the past few years, there has been a nascent convergence of scientific understanding of
inherited human diseases with epigenetics. Identified epigenetic processes involved in …

Epigenetic factors alter phenotype without changing genotype. A primary molecular
mechanism underlying epigenetics is the alteration of chromatin structure by covalent DNA …

Genomes are more than linear sequences. In vivo they exist as elaborate physical
structures, and their functional properties are strongly determined by their cellular …