Using one of the well known mathematical models for immunotherapy of tumor–immune
interactions, in this paper an algorithm is developed to optimize the immunotherapy in …

Abstract Background and Objective There are various approaches to control a mathematical
dynamic of cancer, each of which is suitable for a special goal. Optimal control is considered …

We propose a mathematical model describing tumor‐immune interactions under immune
suppression. These days evidences indicate that the immune suppression related to cancer …

We investigate mathematical models for the dynamics between tumor cells, immune-effector
cells, and cytokine interleukin-2 (IL-2). To better determine under what circumstances the …

In this paper, a therapeutic strategy for the treatment of cancer using immunotherapy that
aims to maximize the active immune response and to minimize the tumor cells level while …

Herein, we present a mathematical model of tumour-immune interactions in presence of
chemotherapy treatment. The model is governed by a system of delay differential equations …

Background Chemotherapy is usually known as the main modality for cancer treatment.
Nevertheless, most of chronic cancers could not be treated with chemotherapy alone …

Clinical immunologists, among other problems, routinely face a question: what is the best
time and dose for a certain therapeutic agent to be administered to the patient in order to …

An Optimal Control Approach to Cancer Chemotherapy with Tumor–Immune System
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The aim of this work is to apply optimal control theory to certain cancer treatment strategies
which based on combination of multiple cancer therapies, in the form of a system of ordinary …