Epigenetic changes in the hypothalamic proopiomelanocortin and glucocorticoid receptor genes in the ovine fetus after periconceptional undernutrition

A Stevens, G Begum, A Cook, K Connor… - …, 2010 - academic.oup.com
Maternal food restriction is associated with the development of obesity in offspring. This
study examined how maternal undernutrition in sheep affects the fetal hypothalamic …

Maternal undernutrition programs tissue-specific epigenetic changes in the glucocorticoid receptor in adult offspring

G Begum, A Davies, A Stevens, M Oliver… - …, 2013 - academic.oup.com
Epidemiological data indicate that an adverse maternal environment during pregnancy
predisposes offspring to metabolic syndrome with increased obesity, and type 2 diabetes …

[HTML][HTML] Epigenetic changes in fetal hypothalamic energy regulating pathways are associated with maternal undernutrition and twinning

G Begum, A Stevens, EB Smith, K Connor… - The FASEB …, 2012 - ncbi.nlm.nih.gov
Undernutrition during pregnancy is implicated in the programming of offspring for the
development of obesity and diabetes. We hypothesized that maternal programming causes …

Epigenetic changes in the hypothalamic pro-opiomelanocortin gene: a mechanism linking maternal undernutrition to obesity in the offspring?

A Stevens, G Begum, A White - European journal of pharmacology, 2011 - Elsevier
Maternal undernutrition is associated with programming of obesity in offspring. While
previous evidence has linked programming to the hypothalamic, pituitary, and adrenal …

Maternal undernutrition in early gestation alters molecular regulation of the hypothalamic‐pituitary‐adrenal axis in the ovine fetus

P Hawkins, MA Hanson… - Journal of …, 2001 - Wiley Online Library
We have demonstrated previously that plasma adrenocorticotropin hormone and cortisol
responses to exogenous and endogenous stimuli are reduced in fetuses of mildly …

Periconceptional undernutrition in sheep accelerates maturation of the fetal hypothalamic-pituitary-adrenal axis in late gestation

FH Bloomfield, MH Oliver, P Hawkins… - …, 2004 - academic.oup.com
We investigated the effects of moderate maternal periconceptional undernutrition from 60 d
before to 30 d after mating on fetal hypothalamic-pituitary-adrenal axis function in late …

Prenatal influences on susceptibility to diet-induced obesity are mediated by altered neuroendocrine gene expression

BA Ikenasio-Thorpe, BH Breier… - Journal of …, 2007 - joe.bioscientifica.com
The escalating rates of obesity and type 2 diabetes have reached pandemic proportions. It
has been proposed that the risk of developing metabolic disorders in adult life is influenced …

Maternal overnutrition programs epigenetic changes in the regulatory regions of hypothalamic Pomc in the offspring of rats

T Gali Ramamoorthy, TJ Allen, A Davies… - International Journal of …, 2018 - nature.com
Background and objective Maternal overnutrition has been implicated in affecting the
offspring by programming metabolic disorders such as obesity and diabetes, by …

Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome

A Plagemann, T Harder, M Brunn… - The Journal of …, 2009 - Wiley Online Library
Pre‐and neonatal overfeeding programmes a permanent obesity disposition and
accompanying diabetic and cardiovascular disorders, by unknown mechanisms. We …

Effect of periconceptional undernutrition and gender on hypothalamic–pituitary–adrenal axis function in young adult sheep

DS Gardner, BWM Van Bon, J Dandrea… - Journal of …, 2006 - joe.bioscientifica.com
Glucocorticoids are proposed to act as intermediary factors that transcribe the
developmental programming sequelae of maternal nutrient restriction (NR) …