The transcription factor Oct4 is key in embryonic stem cell identity and reprogramming.
Insight into its partners should illuminate how the pluripotent state is established and …

Oct4 is a well-known transcription factor that plays fundamental roles in stem cell self-
renewal, pluripotency, and somatic cell reprogramming. However, limited information is …

Mammalian cell totipotency is a subject that has fascinated scientists for generations. A long
lasting question whether some of the somatic cells retains totipotency was answered by the …

The human OCT4 gene can generate at least three transcripts (OCT4A, OCT4B, and
OCT4B1) and four protein isoforms (OCT4A, OCT4B-190, OCT4B-265, and OCT4B-164) by …

Oct4 is a key component of the molecular circuitry which regulates embryonic stem cell
proliferation and differentiation. It is essential for maintenance of undifferentiated, pluripotent …

Pluripotency, a characteristic of cells in the inner cell mass of the mammalian
preimplantation blastocyst as well as of embryonic stem cells, is defined as the ability of a …

Transcription factors, such as Oct4, are critical for establishing and maintaining pluripotent
cell identity. Whereas the genomic locations of several pluripotency transcription factors …

OCT4 was discovered more than two decades ago as a transcription factor specific to early
embryonic development. Early studies with OCT4 were descriptive and looked at …

Cell type specification relies on the capacity of undifferentiated cells to properly respond to
specific differentiation-inducing signals. Using genomic approaches along with loss-and …

Stem cells are characterized by two defining features, the ability to self-renew and to
differentiate into highly specialized cell types. The POU homeodomain transcription factor …