NF-κB regulates the expression of a large number of target genes involved in the immune
and inflammatory response, apoptosis, cell proliferation, differentiation and survival. In this …

NF‐κB is responsible for upregulating gene products that control cell survival. In this study,
we demonstrate that SIRT1, a nicotinamide adenosine dinucleotide‐dependent histone …

Chronic inflammation is a major contributing factor in the pathogenesis of many age-
associated diseases. One central protein that regulates inflammation is NF-κB, the activity of …

SIRT1 is a NAD-dependent deacetylase that regulates a variety of pathways including the
stress protection pathway. SIRT1 deacetylates a number of protein substrates, including …

Inflammation increases the abundance of inducible nitric oxide synthase (iNOS), leading to
enhanced production of nitric oxide (NO), which can modify proteins by S-nitrosylation …

Sirt1 is an NAD+-dependent deacetylase that plays a role in cellular processes such as
transcriptional regulation, stress response, longevity and apoptosis. Sirt1 deacetylates …

Members of the sirtuin (SIRT) family of NAD-dependent deacetylases promote longevity in
multiple organisms. Deficiency of mammalian SIRT6 leads to shortened life span and an …

The SIR2 family of nicotinamide adenosine dinucleotide (NAD)-dependent deacetylases
modulates diverse biological functions in different species, including longevity, apoptosis …

Introduction SIRT2 is a NAD (+)-dependent deacetylases and associated with numerous
processes such as infection, carcinogenesis, DNA damage and cell cycle regulation …

The protein deacetylase SIRT 1 has been recognized to exert its protective effect by directly
deacetylasing histone and many other transcriptional factors including p53. However, the …