The pathogenesis of idiopathic pulmonary fibrosis

WR Coward, G Saini, G Jenkins - Therapeutic advances in …, 2010 - journals.sagepub.com
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with an appalling
prognosis. The failure of anti-inflammatory therapies coupled with the observation that …

Idiopathic pulmonary fibrosis: new insights in its pathogenesis

A Pardo, M Selman - The international journal of biochemistry & cell biology, 2002 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a unique type of chronic fibrosing lung disease of
unknown etiology. The sequence of the pathogenic mechanisms is unknown, but the …

Idiopathic pulmonary fibrosis: pathogenesis and therapeutic approaches

M Selman, VJ Thannickal, A Pardo, DA Zisman… - Drugs, 2004 - Springer
Idiopathic pulmonary fibrosis (IPF), also termed cryptogenic fibrosing alveolitis, is a
clinicopathological syndrome characterised by cough, exertional dyspneoa, basilar crackles …

The leading role of epithelial cells in the pathogenesis of idiopathic pulmonary fibrosis

M Selman, A Pardo - Cellular signalling, 2020 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive and devastating interstitial
lung disease of unknown etiology, where the normal lung architecture is lost and replaced …

[HTML][HTML] Fibrosis of two: Epithelial cell-fibroblast interactions in pulmonary fibrosis

N Sakai, AM Tager - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2013 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is characterized by the progressive and ultimately fatal
accumulation of fibroblasts and extracellular matrix in the lung that distorts its architecture …

Role of epithelial cells in idiopathic pulmonary fibrosis: from innocent targets to serial killers

M Selman, A Pardo - Proceedings of the American Thoracic Society, 2006 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF), a progressive and relentless lung scarring of unknown
etiology, has been recognized as the most lethal interstitial lung disease. Despite the …

Evolving concepts of apoptosis in idiopathic pulmonary fibrosis

VJ Thannickal, JC Horowitz - Proceedings of the American Thoracic …, 2006 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a chronic, relentlessly progressive fibrosing disease of
the lung of unknown etiology. Significant progress has been made in recent years in …

Recent advances in molecular targets and treatment of idiopathic pulmonary fibrosis: focus on TGFβ signaling and the myofibroblast

M Gharaee-Kermani, B Hu, SH Phan… - Current medicinal …, 2009 - ingentaconnect.com
Idiopathic Pulmonary Fibrosis (IPF) is characterized by injury and loss of lung epithelial
cells, accumulation of fibroblasts/myofibroblasts and abnormal remodeling of the lung …

Role of integrin-mediated TGFβ activation in the pathogenesis of pulmonary fibrosis

A Goodwin, G Jenkins - Biochemical Society Transactions, 2009 - portlandpress.com
IPF (idiopathic pulmonary fibrosis) is a chronic progressive disease of unknown aetiology
without effective treatment. IPF is characterized by excessive collagen deposition within the …

[HTML][HTML] Idiopathic pulmonary fibrosis: immunohistochemical analysis provides fresh insights into lung tissue remodelling with implications for novel prognostic …

NJ Lomas, KL Watts, KM Akram… - … journal of clinical and …, 2012 - ncbi.nlm.nih.gov
Aim This study explored the cellular and biological interrelationships involved in Idiopathic
Pulmonary Fibrosis (IPF) lung tissue remodelling using immunohistochemical analysis …