Histone demethylases in chromatin cross‐talks
L Verrier, M Vandromme, D Trouche - Biology of the Cell, 2011 - Wiley Online Library
The 'histone code'hypothesis states that chromatin‐based regulation of nuclear processes
such as transcription is brought about by the combination of distinct modifications (histone …
such as transcription is brought about by the combination of distinct modifications (histone …
Regulation of p53 function by lysine methylation
LE West, O Gozani - Epigenomics, 2011 - Taylor & Francis
The reversible and dynamic methylation of proteins on lysine residues can greatly increase
the signaling potential of the modified factor. In addition to histones, several other nuclear …
the signaling potential of the modified factor. In addition to histones, several other nuclear …
Lysine methylation of promoter-bound transcription factors and relevance to cancer
Abstract p53, NFκB, STAT3, and several other transcription factors are reversibly methylated
on lysine residues by enzymes that also modify histones. The methylations of NFκB and …
on lysine residues by enzymes that also modify histones. The methylations of NFκB and …
Natural history of the eukaryotic chromatin protein methylation system
In eukaryotes, methylation of nucleosomal histones and other nuclear proteins is a central
aspect of chromatin structure and dynamics. The past 15 years have seen an enormous …
aspect of chromatin structure and dynamics. The past 15 years have seen an enormous …
[HTML][HTML] Suppl 1: Targets in Epigenetics: Inhibiting the Methyl Writers of the Histone Code
Growing evidence suggests that protein lysine methyltransferases (PKMTs) and protein
arginine methyltransferases (PRMTs) are associated with the development of various …
arginine methyltransferases (PRMTs) are associated with the development of various …
Emerging roles of epigenetic mechanisms in Parkinson's disease
E Habibi, A Masoudi-Nejad, HM Abdolmaleky… - Functional & integrative …, 2011 - Springer
Epigenetic mechanisms have emerged as important components of a variety of human
diseases, including cancer and central nervous system disorders. Despite recent studies …
diseases, including cancer and central nervous system disorders. Despite recent studies …
Methylation-mediated regulation of E2F1 in DNA damage-induced cell death
E2F1 promotes DNA damage-induced apoptosis and the post-translational modifications of
E2F1 play an important role in the regulation of E2F1-mediated cell death. Here, we found …
E2F1 play an important role in the regulation of E2F1-mediated cell death. Here, we found …
Synthesis of proteins with defined posttranslational modifications using the genetic noncanonical amino acid incorporation approach
Posttranslational modifications modulate the activities of most eukaryotic proteins and play a
critical role in all aspects of cellular life. Understanding functional roles of these …
critical role in all aspects of cellular life. Understanding functional roles of these …
Dynamics of histone lysine methylation: structures of methyl writers and erasers
AK Upadhyay, X Cheng - Epigenetics and Disease: Pharmaceutical …, 2011 - Springer
In Eukarya, the packaging of DNA into chromatin provides a barrier that allows for regulation
of access to the genome. Chromatin is refractory to processes acting on DNA. ATP …
of access to the genome. Chromatin is refractory to processes acting on DNA. ATP …
Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor
D Ogasawara, T Suzuki, K Mino, R Ueda… - Bioorganic & medicinal …, 2011 - Elsevier
Optically active (1S, 2R)-NCL-1 and (1R, 2S)-NCL-1 were synthesized and evaluated for
their lysine-specific demethylase 1 inhibitory activity and cell growth inhibitory activity. In …
their lysine-specific demethylase 1 inhibitory activity and cell growth inhibitory activity. In …