Background Megalin is a large endocytic receptor with relevant functions during
development and adult life. It is expressed at the apical surface of several epithelial cell …

Expression profiling confirms role of endocytic receptor megalin in renal vitamin D 3
metabolism. Background The endocytic receptor megalin constitutes the major pathway for …

Obesity, an important risk factor for metabolic syndrome (MetS) and cardiovascular disease,
is often complicated by CKD, which further increases cardiovascular risk and causes ESRD …

Megalin/LRP2 is a receptor that plays important roles in the physiology of several organs,
such as kidney, lung, intestine, and gallbladder and also in the physiology of the nervous …

The endocytosis mechanism is a complicated system that is essential for cell signaling and
survival. Megalin, a membrane-associated endocytic receptor, and its related proteins such …

Megalin-mediated endocytic uptake constitutes the main pathway for clearance of plasma
proteins from the glomerular filtrate in proximal tubules. Little is known, however, about …

Expression and function of megalin, an endocytic receptor in proximal tubule cells (PTCs),
are reduced in diabetic nephropathy, involved in the development of proteinuria/albuminuria …

Since the discovery of the low-density lipoprotein receptor (LDLR) and its association with
familial hypercholesterolemia in the early 1980s, a family of structurally related proteins has …

Pathogenic variants in the LRP2 gene, encoding the multiligand receptor megalin, cause a
rare autosomal recessive syndrome: Donnai-Barrow/Facio-Oculo-Acoustico-Renal …

Megalin is a member of the low-density lipoprotein receptor superfamily. It has been
recognized as an endocytic receptor for a large spectrum of ligands. As a consequence …