Class B GPCRs comprise a family of receptors for a variety of therapeutically relevant
peptide hormones. Their activity is implicated in several pivotal biological processes …

G-protein-coupled receptors (GPCRs) represent the largest constellation of validated drug
targets. Crystal structures of class A GPCRs have facilitated major advances in …

Family B of G-protein-coupled receptors (GPCRs) and their ligands play a central role in a
number of homeostatic mechanisms in the endocrine, gastrointestinal, skeletal, immune …

Class B G-protein-coupled receptors (GPCRs) are receptors for peptide hormones that
include glucagon, parathyroid hormone, and calcitonin. These receptors are involved in a …

The class B family of G-protein-coupled receptors (GPCRs) regulates essential physiological
functions such as exocrine and endocrine secretions, feeding behaviour, metabolism …

The activation mechanism of class B G-protein-coupled receptors (GPCRs) remains largely
unknown. To characterize conformational changes induced by peptide hormones, we …

G protein‐receptors (GPCRs) of the class B are a small family of peptide receptors
characterized by a large highly structured N‐terminal domain (NTD). Due to the lack of …

Class B GPCR's are activated by peptide ligands, typically 30-40 amino acid residues, that
are involved in major physiological functions such as glucose homeostasis (glucagon and …

Functional and structural studies of family BG protein-coupled receptors By Brian P. Cary A
dissertation submitted in partial f Page 1 Functional and structural studies of family BG …

Members of the class B family of G protein-coupled receptors (GPCRs) bind peptide
hormones and have causal roles in many diseases, ranging from diabetes and osteoporosis …