Background Despite efforts to establish uniform protocols for the management of severe
sepsis, this condition continues to have high morbidity and mortality. This is due, among …

Phase III clinical trials on severe sepsis and septic shock published during the past decade
have failed to reveal the superiority of any therapeutic intervention on mortality compared …

For many years, basic research with relatively straightforward pathophysiologic approaches
has driven clinical trials using molecules that supposedly interfere positively with …

Sepsis is one of the leading and grossly under recognized cause of death in the world. If not
recognized early and treated promptly, sepsis leads to septic shock, multiorgan failure and …

Sepsis is life-threatening and might potentially progress from dysregulation to severe organ
dysfunction. It is recognised by the World Health Organisation as a global health priority. The …

Severe sepsis and septic shock are major healthcare problems with high mortality, ranging
from 20% to 60%, affecting millions of individuals around the world each year. The speed …

Rationale: Several Surviving Sepsis Campaign Guidelines recommendations are
reevaluated. Objectives: To analyze the effectiveness of treatments recommended in the …

PURPOSE: PROGRESS, an international web-based severe sepsis registry, was created to
provide a representative, contemporary description of severe sepsis worldwide. We …

In 2004 the first edition of the “Surviving sepsis campaign” guidelines for the management of
severe sepsis and septic shock was published, opening a new era in the treatment of this …

Severe sepsis and septic shock are conditions with a mortality rate about 50% despite of
advances of antimicrobial treatment and supportive cares. Recently, investigators are trying …