Secretin and its receptor hold special places in history, with secretin representing the first
“hormone”, giving rise to the field of endocrinology when WM Bayliss and EH Starling …

Secretin is one of the “classical” gastrointestinal hormones and in fact was the first peptide
hormone identified. The mature hormone is a 27 amino acid peptide produced and secreted …

This review describes the history of secretin discovery, identification, purification, and
structural determination; cloning of secretin and its receptor; synthetic secretin; and highly …

Only one secretin receptor has been cloned and its properties characterized in native and
transfected cells. To test the hypothesis that stimulatory and inhibitory effects of secretin are …

Secretin, a 27-amino acid gastrointestinal peptide, was initially discovered based on its
activities in stimulating pancreatic juice. In the past 20 years, secretin was demonstrated to …

Results Rat secretin was significantly more potent than other secretins for pancreatic
secretion, in the order of rat> porcine> canine> human. The four secretins significantly …

In collaboration with physiologist WM Bayliss, English physician EH Starling discovered
secretin in 1902. During that era, hormonal control of pancreatic secretions conflicted with …

Secretin was discovered by Starling & Bayliss in 1902. Three years later the hormone
concept and hormonal regulation were described and early regulatory physiology took a …

One hundred years have elapsed since the discovery of secretin by Bayliss and Starling in
1902. In the past century, the research of secretin has gone by many milestones including …

Secretin is an important regulator of pancreatic function, but the molecular basis of its
actions is not well understood. We have, therefore, used in situ autoradiography …