Lipid rafts (LRs) are membrane realms characterized by high concentrations of cholesterol
and sphingolipids. Often, they are portrayed as scaffolds on which many different signaling …

Lipid rafts (LRs) are membrane realms characterized by high concentrations of cholesterol
and sphingolipids. Often, they are portrayed as scaffolds on which many different signaling …

Sphingolipids are intrinsic components of membrane lipid rafts. The abnormal accumulation
of these molecules may introduce architectural and functional changes in these domains …

Krabbe's Disease is caused by mutations in the gene encoding the lysosomal enzyme
galactosylceramidase, leading to loss of normal catabolism of the prominent myelin lipid …

In prior studies, our laboratory showed that psychosine accumulates and disrupts lipid rafts
in brain membranes of Krabbe's disease. A model of lipid raft disruption helped explaining …

Psychosine is a neurotoxic lipid, which accumulates in oligodendrocytes and Schwann cells.
The elevated levels of the cytotoxic lipid may cause the death in the myelin-forming cells …

Psychosine exerts most of its toxic effects by altering membrane dynamics with increased
shedding of extracellular vesicles (EVs). In this study, we discovered that a fraction of …

Psychosine is a lipid raft-associated cytotoxic sphingolipid that accumulates in individual
nervous system affected with Krabbe disease, a deficiency of lysosomal …

Krabbe disease is a rapidly progressive lysosomal storage disorder that primarily affects
infants. Accumulation of psychosine, a cytotoxic substrate, in the myelin-forming cells results …

Krabbe disease is a lethal, demyelinating condition caused by genetic deficiency of
galactocerebrosidase (GALC) and resultant accumulation of its cytotoxic substrate …