Die erfolgreiche Therapie einer Krebserkrankung ist häufig von einer rechtzeitigen
Diagnose und dem damit verbundenen rechtzeitigen Behandlungsbeginn abhängig. Eine …

Secretin was originally discovered as a gastrointestinal peptide that stimulates fluid
secretion from the pancreas and liver and delays gastric emptying. In disease, a secretin …

G protein-coupled receptors (GPCRs) are pharmacologically vital, due to their role in several
diseased conditions like osteoporosis, obesity, cancer, neurodegeneration, diabetes …

Class BG protein-coupled receptors (GPCRs) regulate a wide range of endocrine and
neuroendocrine functions and are endogenously stimulated by moderately large peptide …

Class BG protein-coupled receptors (GPCRs) regulate a wide range of endocrine and
neuroendocrine functions and are endogenously stimulated by moderately large peptide …

The secretin receptor is a prototypic class B GPCR with substantial and broad
pharmacologic importance. The aim of this project was to develop a high affinity selective …

Background & Aims: Pancreatic and bile duct carcinomas represent highly aggressive
malignancies that evolve from secretin receptor-rich ductular cells. With premessenger RNA …

We have identified two basic residues that are important for the recognition of secretin and
vasoactive intestinal peptide (VIP) by their respective receptors. These two peptides …

Secretin and its receptor hold special places in history, with secretin representing the first
“hormone”, giving rise to the field of endocrinology when WM Bayliss and EH Starling …

While it is evident that the carboxyl-terminal region of natural peptide ligands bind to the
amino-terminal domain of class B GPCRs, how their biologically critical amino-terminal …