335 specifically expressed in cones, although it constitutes only 2% of their total arrestin
complement. 5 Non-visual arrestin-2 (first described as β-arrestin) 6 and arrestin-37 (first …

For many years, the primary function of arrestins was believed to be a master regulator of
desensitization of G protein–coupled receptors (GPCRs) by the following mechanism. Upon …

Arrestins are structurally flexible and functionally versatile proteins that regulate the activity
of hundreds of different G protein-coupled receptors (GPCRs). A hallmark of arrestin function …

The arrestins, a small family of versatile adapter proteins, play central roles in G-protein
coupled receptor (GPCR) desensitization, endocytosis, and signal transduction. Two papers …

Arrestins are characterized by their ability to selectively bind active, phosphorylated GPCRs
and suppress (arrest) receptor coupling to G proteins. Nonvisual arrestins are also signaling …

Highlights•Recent crystal structures indicate how arrestin is activated for GPCR
binding.•Multiple binding sites for phosphorylated receptor C-terminus exist on …

Arrestins function as adapter proteins that mediate G protein-coupled receptor (GPCR)
desensitization, internalization, and additional rounds of signaling. Here we have compared …

The 4 mammalian arrestins serve as almost universal regulators of the largest known family
of signaling proteins, G-protein-coupled receptors (GPCRs). Arrestins terminate receptor …

Cellular functions of arrestins are determined in part by the pattern of phosphorylation on the
G protein-coupled receptors (GPCRs) to which arrestins bind. Despite high-resolution …

Arrestins are a small family of four proteins in most vertebrates that bind hundreds of
different G protein-coupled receptors (GPCRs). Arrestin binding to a GPCR has at least three …