The vast majority of neurodegenerative disorders are adult-onset, incurable diseases.
Understanding the pathogenetic mechanisms underlying these disorders and finding …

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder that is
characterized by the irreversible loss of corticospinal neurons and motor neurons. Recent …

Recent evidence highlights the peroxisome proliferator-activated receptors (PPARs) as
critical neuroprotective factors in several neurodegenerative diseases, including …

Amyotrophic lateral sclerosis (ALS) represents a fatal neurodegenerative disorder
characterized by progressive death of the upper and lower motor neurons. Because …

Accumulating evidence suggests that inflammation plays a major role in the pathogenesis of
motoneuron death in amyotrophic lateral sclerosis (ALS) both in humans and transgenic …

Amyotrophic lateral sclerosis (ALS) is a debilitating and one of the most common adult‐
onset neurodegenerative diseases with the prevalence of about 5 per 100 000 individuals. It …

Activation of peroxisome proliferator-activated receptors (PPARs) mediates the insulin-
sensitizing effects of thiazolidinediones used for treatment of type 2 diabetes, owing to …

Neuroinflammation, immune reactivity and mitochondrial abnormalities are considered as
causes and/or contributors to neuronal degeneration. Peroxisome proliferator-activated …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with limited
therapeutic options. Clinical trials of several drugs shown to be effective in the superoxide …

Emerging evidence suggests the involvement of programmed cell death and inflammation in
amyotrophic lateral sclerosis (ALS). To assess molecular pathological effects of the anti …