A number of histone demethylases have been identified and biochemically characterized,
but the pathological roles of their dysfunction in human disease like cancer have not been …

Background: Emerging evidence has demonstrated that lysine-specific demethylase 1
(LSD1) has an important role in many pathological processes of cancer cells, such as …

Studies of alterations in histone methylation in cancer have led to the identification of histone
methyltransferases and demethylases as novel targets for therapy. Lysine-specific …

Epigenetic silencing of gene expression is important in cancer. Aberrant DNA CpG island
hypermethylation and histone modifications are involved in the aberrant silencing of tumour …

Abstract Lysine-specific demethylase 1 (LSD1) targets mono-or di-methylated histone H3K4
and H3K9 as well as non-histone substrates and functions in the regulation of gene …

Background Lysine specific demethylase 1 (LSD1) has been identified and biochemically
characterized in epigenetics, but the pathological roles of its dysfunction in lung cancer …

Histone methylation plays a key role in the regulation of chromatin structure, and its
dynamics regulates important cellular processes. The investigation of the role of alterations …

Lysine-specific histone demethylase 1 (LSD1) represents the first example of an identified
nuclear protein with histone demethylase activity. In particular, it plays a special role in the …

The histone demethylase LSD1 (lysine specific demethylase 1) plays an important role in
the epigenetic regulation of gene transcription. Our study investigated the role of LSD1 in …

Histone demethylases play important roles in various biological processes in a manner
dependent on their demethylase activities. However, little is known about their demethylase …