[HTML] nih.gov

PAC1hop, null and hip receptors mediate differential signaling through cyclic AMP and calcium leading to splice variant-specific gene induction in neural cells

Y Holighaus, T Mustafa, LE Eiden - Peptides, 2011 - Elsevier
Pituitary adenylate cyclase-activating polypeptide (PACAP)-mediated activation of its G
protein-coupled receptor PAC1 results in activation of the two G proteins Gs and Gq to alter …
被引用次数：48 相关文章 所有 13 个版本

Differential intracellular signaling through PAC1 isoforms as a result of alternative splicing in the first extracellular domain and the third intracellular loop

M Ushiyama, R Ikeda, H Sugawara, M Yoshida… - Molecular …, 2007 - ASPET
Pituitary adenylate cyclase-activating polypeptide (PACAP), a pleiotropic neuropeptide,
performs a variety of physiological functions. The PACAP-specific receptor PAC1 has …
被引用次数：47 相关文章 所有 6 个版本
[HTML] jbc.orgFull View

[HTML][HTML] The hop cassette of the PAC1 receptor confers coupling to Ca2+ elevation required for pituitary adenylate cyclase-activating polypeptide-evoked …

T Mustafa, M Grimaldi, LE Eiden - Journal of biological chemistry, 2007 - ASBMB
We have identified the single PAC1 receptor variant responsible for Ca 2+ mobilization from
intracellular stores and influx through voltage-gated Ca 2+ channels in bovine chromaffin …
被引用次数：53 相关文章 所有 11 个版本
[HTML] nih.gov

STC1 induction by PACAP is mediated through cAMP and ERK1/2 but not PKA in cultured cortical neurons

Y Holighaus, E Weihe, LE Eiden - Journal of Molecular Neuroscience, 2012 - Springer
The neuroprotective actions of PACAP (pituitary adenylate cyclase-activating polypeptide) in
vitro and in vivo suggest that activation of its cognate G protein-coupled receptor PAC1 or …
被引用次数：23 相关文章 所有 10 个版本
[PDF] researchgate.net

Transcription of the mouse PAC1 receptor gene: cell-specific expression and regulation by Zac1

N Rodrı́guez-Henche, F Jamen, C Leroy… - … et Biophysica Acta (BBA …, 2002 - Elsevier
Regulations of the PACAP type 1 (PAC1) receptor expression have been described in the
brain and the anterior pituitary. To understand the molecular mechanisms underlying mouse …
被引用次数：32 相关文章 所有 8 个版本

Characterization of the PAC1 variants expressed in the mouse heart

M Ushiyama, H Sugawara, K Inoue… - Annals of the New …, 2006 - Wiley Online Library
Pituitary adenylate cyclase‐activating polypeptide (PACAP), a pleiotropic neuropeptide,
exerts a variety of physiological functions through three types of G protein–coupled …
被引用次数：14 相关文章 所有 7 个版本
[PDF] academia.edu

Splice variants of PAC1 receptor during early neural development of rats

CJ Zhou, S Kikuyama, S Nakajo, T Hirabayashi… - Peptides, 2000 - Elsevier
The specific pituitary adenylate cyclase-activating polypeptide (PACAP) receptor, PAC1-R,
consists of at least seven isoforms, and they are differentially coupled to signal transduction …
被引用次数：14 相关文章 所有 6 个版本
[HTML] plos.org

[HTML][HTML] β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking

Y Shintani, A Hayata-Takano, K Moriguchi… - PLoS …, 2018 - journals.plos.org
A pituitary adenylate cyclase-activating polypeptide (PACAP)-specific receptor, PAC1R, is
coupled with multiple signal transduction pathways including stimulation of adenylate …
被引用次数：27 相关文章 所有 10 个版本

Identification by photoaffinity labeling of the extracellular N-terminal domain of PAC1 receptor as the major binding site for PACAP

A Dejda, S Bourgault, ND Doan, M Létourneau… - Biochimie, 2011 - Elsevier
Pituitary adenylate cyclase-activating polypeptide (PACAP) exerts many crucial biological
functions through the interaction with its specific PAC1 receptor (PAC1-R), a class BG …
被引用次数：31 相关文章 所有 6 个版本

Altered emotional behavior in PACAP-type-I-receptor-deficient mice

C Otto, M Martin, DP Wolfer, HP Lipp… - Molecular Brain …, 2001 - Elsevier
PAC1 (pituitary adenylate cyclase activating polypeptide type I receptor) is a G-protein-
coupled receptor that binds the strongly conserved neuropeptide PACAP (pituitary …
被引用次数：166 相关文章 所有 9 个版本