Fluoroquinolones are broad-spectrum antibacterial agents based on the structure of
nalidixic acid. For nearly five decades it has been known that fluoroquinolones inhibit …

Fluoroquinolones, broad-spectrum bactericidal antibiotics, exert their effects by inhibiting
type II topoisomerases through the formation of a fluoroquinolone-DNA-topoisomerase …

The quinolones are a potent group of drugs that target the essential bacterial enzymes DNA
gyrase and topoisomerase IV. DNA gyrase is the primary target of Gram negative organisms …

Direct Toxicity Against Eukaryotic Cells Fluoroquinolones are a class of antimicrobial agents
that have activity directed at prokaryotic topoisomerases including topoisomerase II (DNA …

Fluoroquinolones are potent inhibitors of bacterialtopoisomerase II (DNA gyrase). They can
also inhibit eukaryotic topoisomerases, which could possibly lead to clastogenicityand/or …

When fluoroquinolones bind to gyrase or topoisomerase IV in the presence of DNA, they
alter protein conformation. DNA cleavage results with diminished religation, so the enzymes …

Fluoroquinolones are synthetic antibacterial agents that stabilize the ternary complex of
prokaryotic topoisomerase II enzymes (gyrase and Topo IV), leading to extensive DNA …

Fluoroquinolone antibiotics, such as ciprofloxacin, levofloxacin, and moxifloxacin, have
enjoyed enormous success over the past few decades. However, resistance to these …

The mode of action of quinolones involves interactions with both DNA gyrase, the originally
recognised drug target, and topoisomerase IV, a related type II topoisomerase. In a given …

Fluoroquinolones are antibacterial agents that attack DNA gyrase and topoisomerase IV on
chromosomal DNA. The existence of two fluoroquinolone targets and stepwise accumulation …