The ISCOMATRIX adjuvant has antigen delivery and presentation properties as well as
immunomodulatory capabilities, which combine to provide enhanced and accelerated …

Disease tolerance is a defense strategy that limits the fitness costs of infection irrespectively
of pathogen burden. While restricting iron (Fe) availability to pathogens is perceived as a …

Liposomes containing monophosphoryl lipid A (MPLA) have previously exhibited
considerable potency and safety in human trials with a variety of candidate vaccines …

Malaria is an important human disease and is the target of a global eradication campaign.
New technological and informatics advancements in population genomics are being …

Abstract The Nanoro Health and Demographic Surveillance System (HDSS), located in the
rural centre of Burkina Faso, was established in 2009 by the Clinical Research Unit of …

Pre-erythrocytic malaria vaccines target Plasmodium during its sporozoite and liver stages,
and can prevent progression to blood-stage disease, which causes a million deaths each …

Circumsporozoite (CS) protein is the major surface component of Plasmodium falciparum
sporozoites and is essential for host cell invasion. A vaccine containing tandem repeats …

Background Malaria remains a major human health problem, with no licensed vaccine
currently available. Malaria infections initiate when infectious Plasmodium sporozoites are …

Malaria remains a major world health problem following the emergence and spread of
Plasmodium falciparum that is resistant to the majority of antimalarial drugs. This problem …

Despite the protection provided by several factors, including maternal antibodies, the burden
of malaria in young infants may be higher than previously thought. Infants with congenital or …