Novel drug targets in malaria parasite with potential to yield antimalarial drugs with long useful therapeutic lives

FW Muregi, H Nyakio Wamakima… - Current pharmaceutical …, 2012 - ingentaconnect.com
The status of chemotherapy as the main strategy in malaria control is rapidly being eroded
by development of drug resistant Plasmodia, causing malaria to be dubbed a “re-emerging …

Enhancement of naturally acquired immunity against malaria by drug use

EM Bijker, RW Sauerwein - Journal of medical …, 2012 - microbiologyresearch.org
Combination of chemoprophylaxis with chloroquine and so-called 'controlled human malaria
infections' has been shown to induce sustained and fully protective immunity against malaria …

Malaria in the post-genome era

B Greenwood, S Owusu-Agyei - Science, 2012 - science.org
Ten years ago, the genome sequence of the mosquito Anopheles gambiae, the most
important vector of malaria in Africa, and the genome sequence of Plasmodium falciparum …

Low-concentration copper solution jeopardizes larval movement and ability to survive predation: New insight into malaria eradication via vector control

M Reza, DS Yamamoto, H Matsuoka - Medical Entomology and …, 2012 - jstage.jst.go.jp
A new approach to eradicating malaria is urgently required. Emphasizing vector eradication
via larval control, we tried to find a safe concentration of copper, which can be utilized to …

In vitro activity of Pheroid vesicles containing antibiotics against Plasmodium falciparum

LH Du Plessis, AC Van Niekerk, MM Maritz… - The Journal of …, 2012 - nature.com
The macrolide antibiotics, erythromycin and azithromycin, have been studied for their
potential antimalarial activity, but only modest activity has been demonstrated. In this study …

Future prevention and treatment of chronic hepatitis B infection

WK Seto, J Fung, MF Yuen, CL Lai - Journal of clinical …, 2012 - journals.lww.com
Vaccination for hepatitis B virus (HBV) infection and treatment for chronic hepatitis B, while
effective for primary prevention and control of the disease, still have their limitations. Global …

A flow cytometry-based workflow for detection and quantification of anti-plasmodial antibodies in vaccinated and naturally exposed individuals

A Ajua, T Engleitner, M Esen, M Theisen, S Issifou… - Malaria Journal, 2012 - Springer
Background Antibodies play a central role in naturally acquired immunity against
Plasmodium falciparum. Current assays to detect anti-plasmodial antibodies against native …

Virus-like particles as efficient delivery platform to induce a potent immune response

F Rebeaud, M Bachmann - … in Vaccinology: from design, through to …, 2012 - Springer
Virus-like particles (VLPs) are spontaneously formed structures upon self-assembly of viral
capsid proteins. Similar to viruses, VLPs have a repetitive surface structure and an optimal …

Age of infection and risk of virally associated cancers: new clues to an old puzzle

R Bagni, D Whitby - Journal of Infectious Diseases, 2012 - academic.oup.com
Endemic Burkitt lymphoma is a puzzling disease caused by Epstein–Barr virus (EBV) that
occurs in children in sub-Saharan Africa, where it is the most common childhood …

Exploiting structural biology in the fight against parasitic diseases

Y Modis - Trends in parasitology, 2012 - cell.com
Despite spectacular advances in structural biology over the past half-century, only
approximately 2% of the structures in the Protein Data Bank are from eukaryotic parasites …