Lysine methylation and the regulation of p53
SM Carr, S Munro, NBL Thangue - Essays in biochemistry, 2012 - portlandpress.com
The p53 tumour suppressor protein functions as a guardian against genotoxic stress. This
function is mediated in part by the transcriptional activation of genes involved in cell-cycle …
function is mediated in part by the transcriptional activation of genes involved in cell-cycle …
Epigenetik mekanizmalar ve kanser
ÖF Hatipoğlu, E Kaya, E Yaykaşlı… - Duzce Medical …, 2012 - dergipark.org.tr
Epigenetics, proposed by Condrad Hal Waddington at the begining of the 1940
describesheritable changes that affect gene expression without changing DNA sequencing …
describesheritable changes that affect gene expression without changing DNA sequencing …
Polyamine metabolism and signaling in plant abiotic stress protection
R Alcázar Hernández, M Bitrián, X Zarza… - Recent Advances in …, 2012 - diposit.ub.edu
Polyamines (PAs) are small polycationic compounds present in all living organisms.
Compelling evidences indicate a role for PAs in plant protection against stress. During the …
Compelling evidences indicate a role for PAs in plant protection against stress. During the …
Epigenetics—an emerging and highly promising source of new drug targets
N Carey - MedChemComm, 2012 - pubs.rsc.org
Epigenetic modifications to DNA and its associated histoneproteins are major influences on
gene expression. This regulatory process is disrupted in cancer and a range of chronic …
gene expression. This regulatory process is disrupted in cancer and a range of chronic …
Transgenic lsd1 animal model for cancer
R Schuele, T Guenther, E Metzger - US Patent App. 13/376,212, 2012 - Google Patents
The present invention relates to a non-human transgenic animal whose genome comprises
a stably integrated transgenic nucleotide sequence encoding Lysine-specific Demethylase 1 …
a stably integrated transgenic nucleotide sequence encoding Lysine-specific Demethylase 1 …
LSD1 通过和Oct4/Nanog 相互作用调节诱导多能干细胞的形成
孙昊， 卢存福， 郭允倩 - 中国生物工程杂志, 2012 - manu60.magtech.com.cn
将4 个转录因子Oct4, Sox2, Klf4 和c-Myc 转入成纤维细胞可以生成诱导多能干细胞(iPS 细胞),
转录因子和染色质修饰因子在这个过程中起重要作用. LSD1 作为染色质结构的调节因子 …
转录因子和染色质修饰因子在这个过程中起重要作用. LSD1 作为染色质结构的调节因子 …
Modulation of cell death pathways in cancer stem cells: Targeting histone demethylases
Cancer stem cells (CSCs) are tumor initiating cells within the tumor mass; that play a critical
role in cancer pathogenesis. CSCs regulate cancer cell survival, metastatic potential …
role in cancer pathogenesis. CSCs regulate cancer cell survival, metastatic potential …
[PDF][PDF] 赖氨酸特异性组蛋白去甲基化酶1 作用机制及其生物学功能的研究进展
翟曜耀， 刘晓霞， 赵越 - 生命科学, 2012 - lifescience.sinh.ac.cn
与其他化学修饰, 如乙酰化, 磷酸化, 泛素化等相似, 组蛋白赖氨酸甲基化是一个可以逆转的组
蛋白修饰, 是一个动态调节的过程. 赖氨酸特异性组蛋白去甲基化酶1 (lysine specific …
蛋白修饰, 是一个动态调节的过程. 赖氨酸特异性组蛋白去甲基化酶1 (lysine specific …