The naturally occurring pyrrolysine (Pyl) incorporation machinery was discovered in
methanogenic archaea and some bacteria. In these organisms, Pyl is cotranslationally …

Epigenetic deregulation contributes significantly to the development of multiple human
diseases, including cancer. While great effort has been made to elucidate the underlying …

Estrogen receptors (ERα and ERβ) belong to the ligand-dependent nuclear receptors (NRs),
activated by the binding of 17β-estradiol (E2), a predominantly naturally occurring estrogen …

The tumor suppressor p53 acts as a master transcription factor that controls hundreds of
effecter genes in response to various cellular stresses. The flexibility of p53 to regulate its …

Human adult cartilage is an aneural and avascular type of connective tissue, which
consequently reflects reduced growth and repair rates. The main cell type of cartilage are …

Protein methylation on arginine and lysine residues is a largely unexplored posttranslational
modification which regulates diverse cellular processes. The development of efficient …

Classically, the development of tumour can be explained as a process involving mutations
that either activate growth-promoting genes or inactivate proteins that inhibit growth or …

Alterations in phosphorylation-dependent signalling pathways, accumulation of aggregated
proteins in the brain and neuronal apoptosis are common to neurodegeneration and …

Genes which protect cells from malignant transformation were referred to as tumor
suppressor genes (TSGs). Since the first description of TSG, Rb (retinoblastoma …

BACKGROUND The mono, di-and trimethylation of particular lysine residues in histone tails
(eg histone H3 lysine-4 (H3K4), H3K9, H3K27, H3K36, H4K20) are implicated, along with a …