Thinking through postoperative cognitive dysfunction: how to bridge the gap between clinical and pre-clinical perspectives

IB Hovens, RG Schoemaker, EA van der Zee… - Brain, behavior, and …, 2012 - Elsevier
Following surgery, patients may experience cognitive decline, which can seriously reduce
quality of life. This postoperative cognitive dysfunction (POCD) is mainly seen in the elderly …

Post-operative cognitive dysfunction: an exploration of the inflammatory hypothesis and novel therapies

DR Skvarc, M Berk, LK Byrne, OM Dean, S Dodd… - Neuroscience & …, 2018 - Elsevier
Abstract Post-Operative Cognitive Dysfunction (POCD) is a highly prevalent condition with
significant clinical, social and financial impacts for patients and their communities. The …

[HTML][HTML] The role of neuroinflammation in postoperative cognitive dysfunction: moving from hypothesis to treatment

SA Safavynia, PA Goldstein - Frontiers in psychiatry, 2019 - frontiersin.org
Postoperative cognitive dysfunction (POCD) is a common complication of the surgical
experience and is common in the elderly and patients with preexisting neurocognitive …

The neuroinflammatory response of postoperative cognitive decline

S Vacas, V Degos, X Feng, M Maze - British medical bulletin, 2013 - academic.oup.com
Background Aseptic surgical trauma provokes a homeostatic neuroinflammatory response to
promote healing and protect the organism from further injury. When this response is …

Emerging roles of immune cells in postoperative cognitive dysfunction

Y Liu, Y Yin - Mediators of inflammation, 2018 - Wiley Online Library
Postoperative cognitive dysfunction (POCD), a long‐lasting cognitive decline after surgery,
is currently a major clinical problem with no clear pathophysiological mechanism or effective …

Identification of individuals at risk for postoperative cognitive dysfunction (POCD)

X Yang, X Huang, M Li, Y Jiang… - Therapeutic advances …, 2022 - journals.sagepub.com
Postoperative cognitive dysfunction (POCD) is common, occurring in around 10-54% of
individuals within first few weeks after surgery. Although the majority of POCD is less …

Neuroinflammatory markers associate with cognitive decline after major surgery: findings of an explorative study

M Danielson, A Wiklund, F Granath… - Annals of …, 2020 - Wiley Online Library
Objective Long‐term cognitive decline is an adverse outcome after major surgery associated
with increased risk for mortality and morbidity. We studied the cerebrospinal fluid (CSF) and …

Postoperative cognitive dysfunction in the aged: the collision of neuroinflammaging with perioperative neuroinflammation

AL Luo, J Yan, XL Tang, YL Zhao, BY Zhou… - Inflammopharmacology, 2019 - Springer
The aging population is burgeoning globally and this trend presents great challenges to the
current healthcare system as the growing number of aged individuals receives procedures …

Postoperative cognitive dysfunction: involvement of neuroinflammation and neuronal functioning

IB Hovens, RG Schoemaker, EA van der Zee… - Brain, behavior, and …, 2014 - Elsevier
Postoperative cognitive dysfunction (POCD) has been hypothesized to be mediated by
surgery-induced inflammatory processes, which may influence neuronal functioning either …

[HTML][HTML] Surgery, neuroinflammation and cognitive impairment

A Alam, Z Hana, Z Jin, KC Suen, D Ma - EBioMedicine, 2018 - thelancet.com
Trauma experienced during surgery can contribute to the development of a systemic
inflammatory response that can cause multi-organ dysfunction or even failure. Post-surgical …