Rat brain pro-oxidant effects of peripherally administered 5 nm ceria 30 days after exposure

SS Hardas, R Sultana, G Warrier, M Dan, RL Florence… - Neurotoxicology, 2012 - Elsevier
The objective of this study was to determine the residual pro-or anti-oxidant effects in rat
brain 30 days after systemic administration of a 5nm citrate-stabilized ceria dispersion. A∼ …

Brain distribution and toxicological evaluation of a systemically delivered engineered nanoscale ceria

SS Hardas, DA Butterfield, R Sultana… - Toxicological …, 2010 - academic.oup.com
Engineered nanoscale ceria is used as a diesel fuel catalyst. Little is known about its
mammalian central nervous system effects. The objective of this paper is to characterize the …

Biodistribution and oxidative stress effects of a systemically-introduced commercial ceria engineered nanomaterial

RA Yokel, RL Florence, JM Unrine, MT Tseng… - …, 2009 - Taylor & Francis
The objective was to characterize the biodistribution of nanoscale ceria from blood and its
effects on oxidative stress endpoints. A commercial 5% crystalline ceria dispersion in water …

Rat hippocampal responses up to 90 days after a single nanoceria dose extends a hierarchical oxidative stress model for nanoparticle toxicity

SS Hardas, R Sultana, G Warrier, M Dan, P Wu… - …, 2014 - Taylor & Francis
Ceria engineered nanomaterials (ENMs) have very promising commercial and therapeutic
applications. Few reports address the effects of nanoceria in intact mammals, let alone long …

Distribution, elimination, and biopersistence to 90 days of a systemically introduced 30 nm ceria-engineered nanomaterial in rats

RA Yokel, TC Au, R MacPhail, SS Hardas… - Toxicological …, 2012 - academic.oup.com
Nanoceria is used as a catalyst in diesel fuel, as an abrasive in printed circuit manufacture,
and is being pursued as an antioxidant therapeutic. Our objective is to extend previous …

In vivo processing of ceria nanoparticles inside liver: Impact on free‐radical scavenging activity and oxidative stress

UM Graham, MT Tseng, JB Jasinski, RA Yokel… - …, 2014 - Wiley Online Library
The cytotoxicity of ceria ultimately lies in its electronic structure, which is defined by the
crystal structure, composition, and size. Despite previous studies focused on ceria uptake …

Bio‐distribution and in vivo antioxidant effects of cerium oxide nanoparticles in mice

SM Hirst, A Karakoti, S Singh, W Self… - Environmental …, 2013 - Wiley Online Library
Cerium oxide nanoparticles have oxygen defects in their lattice structure that enables them
to act as a regenerative free radical scavenger in a physiological environment. We …

Biodistribution and biopersistence of ceria engineered nanomaterials: size dependence

RA Yokel, MT Tseng, M Dan, JM Unrine… - … , Biology and Medicine, 2013 - Elsevier
The aims were to determine the biodistribution, translocation, and persistence of nanoceria
in the brain and selected peripheral organs. Nanoceria is being studied as an anti-oxidant …

Neuroprotective mechanisms of cerium oxide nanoparticles in a mouse hippocampal brain slice model of ischemia

AY Estevez, S Pritchard, K Harper, JW Aston… - Free Radical Biology …, 2011 - Elsevier
Cerium oxide nanoparticles (nanoceria) are widely used as catalysts in industrial
applications because of their potent free radical-scavenging properties. Given that free …

Short-term biodistribution of cerium oxide nanoparticles in mice: focus on brain parenchyma

C Portioli, D Benati, Y Pii, P Bernardi… - Nanoscience and …, 2013 - ingentaconnect.com
Cerium oxide nanoparticles, nanoceria, have been proposed as drug delivery devices and
therapeutic tools also for neurological diseases due to their antioxidant properties and …