The induction of cellular immunity, in conjunction with antibodies, may be essential for
vaccines to protect against blood-stage infection with the human malaria parasite …

Efficacy trials of antibody-inducing protein-in-adjuvant vaccines targeting the blood-stage
Plasmodium falciparum malaria parasite have so far shown disappointing results. The …

The development of protective vaccines against many difficult infectious pathogens will
necessitate the induction of effective antibody responses. Here we assess humoral immune …

Background Heterologous prime boost immunization with chimpanzee adenovirus 63
(ChAd63) and Modified vaccinia Virus Ankara (MVA) vectored vaccines is a strategy recently …

Malaria is a major health problem as nearly half of the human population is exposed to this
parasite causing around 600 million clinical cases annually. Prime-boost regimes using …

Background Traditionally, vaccine development against the blood-stage of Plasmodium
falciparum infection has focused on recombinant protein-adjuvant formulations in order to …

Background Plasmodium falciparum (P. falciparum) malaria remains a significant cause of
mortality and morbidity throughout the world. Development of an effective vaccine would be …

The development of effective vaccines against difficult disease targets will require the
identification of new subunit vaccination strategies that can induce and maintain effective …

Although merozoite surface protein 1 (MSP-1) is a leading candidate vaccine antigen for
blood-stage malaria, its efficacy in clinical trials has been limited in part by antigenic …

We assessed a combination multi-stage malaria vaccine schedule in which RTS, S/AS01B
was given concomitantly with viral vectors expressing multiple-epitope thrombospondin …