Ceria-engineered nanomaterial distribution in, and clearance from, blood: size matters

M Dan, P Wu, EA Grulke, UM Graham, JM Unrine… - …, 2012 - Taylor & Francis
Aims: Characterize different sized ceria-engineered nanomaterial (ENM) distribution in, and
clearance from, blood (compared to the cerium ion) following intravenous infusion. Materials …

Nanoceria biodistribution and retention in the rat after its intravenous administration are not greatly influenced by dosing schedule, dose, or particle shape

RA Yokel, JM Unrine, P Wu, B Wang… - Environmental Science …, 2014 - pubs.rsc.org
A 30 nm ceria was previously shown to be primarily cleared from systemic circulation into
mononuclear phagocyte system organs after its intravenous (IV) administration, where it …

Biodistribution and biopersistence of ceria engineered nanomaterials: size dependence

RA Yokel, MT Tseng, M Dan, JM Unrine… - … , Biology and Medicine, 2013 - Elsevier
The aims were to determine the biodistribution, translocation, and persistence of nanoceria
in the brain and selected peripheral organs. Nanoceria is being studied as an anti-oxidant …

Brain microvascular endothelial cell association and distribution of a 5 nm ceria engineered nanomaterial

M Dan, MT Tseng, P Wu, JM Unrine… - International Journal …, 2012 - Taylor & Francis
Purpose Ceria engineered nanomaterials (ENMs) have current commercial applications and
both neuroprotective and toxic effects. Our hypothesis is that ceria ENMs can associate with …

Physiologically based pharmacokinetic modeling of nanoceria systemic distribution in rats suggests dose-and route-dependent biokinetics

U Carlander, TP Moto, AA Desalegn… - International Journal …, 2018 - Taylor & Francis
Background Cerium dioxide nanoparticles (nanoceria) are increasingly being used in a
variety of products as catalysts, coatings, and polishing agents. Furthermore, their …

Biodistribution and oxidative stress effects of a systemically-introduced commercial ceria engineered nanomaterial

RA Yokel, RL Florence, JM Unrine, MT Tseng… - …, 2009 - Taylor & Francis
The objective was to characterize the biodistribution of nanoscale ceria from blood and its
effects on oxidative stress endpoints. A commercial 5% crystalline ceria dispersion in water …

Exploring the long-term tissue accumulation and excretion of 3 nm cerium oxide nanoparticles after single dose administration

LM Ernst, L Mondragón, J Ramis, MF Gustà, T Yudina… - Antioxidants, 2023 - mdpi.com
Nanoparticle (NP) pharmacokinetics significantly differ from traditional small molecule
principles. From this emerges the need to create new tools and concepts to harness their full …

Short-term biodistribution of cerium oxide nanoparticles in mice: focus on brain parenchyma

C Portioli, D Benati, Y Pii, P Bernardi… - Nanoscience and …, 2013 - ingentaconnect.com
Cerium oxide nanoparticles, nanoceria, have been proposed as drug delivery devices and
therapeutic tools also for neurological diseases due to their antioxidant properties and …

Endocytosis of cerium oxide nanoparticles and modulation of reactive oxygen species in human ovarian and colon cancer cells

JA Vassie, JM Whitelock, MS Lord - Acta biomaterialia, 2017 - Elsevier
Cerium oxide nanoparticles (nanoceria) are widely reported to be cytocompatible and
modulate intracellular reactive oxygen species (ROS) in a range of different cell types. In this …

Distribution, elimination, and biopersistence to 90 days of a systemically introduced 30 nm ceria-engineered nanomaterial in rats

RA Yokel, TC Au, R MacPhail, SS Hardas… - Toxicological …, 2012 - academic.oup.com
Nanoceria is used as a catalyst in diesel fuel, as an abrasive in printed circuit manufacture,
and is being pursued as an antioxidant therapeutic. Our objective is to extend previous …