Quercetin and its metabolites improve vessel function by inducing eNOS activity via phosphorylation of AMPK

Y Shen, KD Croft, JM Hodgson, R Kyle, ILE Lee… - Biochemical …, 2012 - Elsevier
Quercetin is a major flavonoid in a wide range of fruits and vegetables. Consumption of
quercetin may contribute to a reduction in risk of cardiovascular disease (CVD). Following …

Dietary flavonoid quercetin stimulates vasorelaxation in aortic vessels

NKH Khoo, CR White, L Pozzo-Miller, F Zhou… - Free Radical Biology …, 2010 - Elsevier
Considerable epidemiological evidence indicates that dietary consumption of moderate
levels of polyphenols decreases both the incidence of cardiovascular disease and the …

Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC

M Romero, R Jiménez, M Sánchez… - Atherosclerosis, 2009 - Elsevier
Chronic administration of the most abundant dietary flavonoid quercetin exerts
antihypertensive effects and improves endothelial function. We have investigated the effects …

Quercetin induces rapid eNOS phosphorylation and vasodilation by an Akt-independent and PKA-dependent mechanism

PG Li, L Sun, X Han, S Ling, W Gan, JW Xu - Pharmacology, 2012 - karger.com
Consumption of the flavonoid quercetin exerts beneficial effects on many chronic diseases.
The mechanisms involved in the vasorelaxant effect of quercetin remain uncertain. In the …

The flavonoid quercetin induces apoptosis and inhibits JNK activation in intimal vascular smooth muscle cells

F Perez-Vizcaino, D Bishop-Bailley, F Lodi… - Biochemical and …, 2006 - Elsevier
Quercetin, the most abundant dietary flavonol, exerts vasodilator, anti-hypertensive, and anti-
atherogenic effects and reduces the vascular remodelling associated with elevated blood …

Concentration-dependent differential effects of quercetin on rat aortic smooth muscle cells

CM Shih, H Lin, YC Liang, WS Lee, WF Bi… - European journal of …, 2004 - Elsevier
Quercetin is one of the most ubiquitous bioflavonoids in foods of plant origin. Although
quercetin is generally considered to provide protection against oxidative injury and …

Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9

SK Moon, GO Cho, SY Jung, SW Gal, TK Kwon… - Biochemical and …, 2003 - Elsevier
The French paradox has been attributed to the antioxidant properties of flavonoids present
in the red wine. Quercetin, a bioflanoid present in the human diet, is known to inhibit …

Quercetin glucuronide prevents VSMC hypertrophy by angiotensin II via the inhibition of JNK and AP-1 signaling pathway

M Yoshizumi, K Tsuchiya, Y Suzaki, K Kirima… - Biochemical and …, 2002 - Elsevier
We previously reported that quercetin, a bioflavonoid belonging to polyphenols, inhibited
Angiotensin II (Ang II)-induced vascular smooth muscle cell (VSMC) hypertrophy through the …

Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta

F Lodi, R Jimenez, L Moreno, PA Kroon, PW Needs… - Atherosclerosis, 2009 - Elsevier
Epidemiological studies have reported an inverse association between dietary flavonoid
intake and mortality for ischemic heart disease. Quercetin reduces blood pressure and …

Pharmacology in health food: metabolism of quercetin in vivo and its protective effect against arteriosclerosis

K Ishizawa, M Yoshizumi, Y Kawai, J Terao… - Journal of …, 2011 - jstage.jst.go.jp
Quercetin, a member of the bioflavonoids family, has been proposed to have
antiatherogenic, anti-inflammatory, and anti-hypertensive properties leading to the beneficial …