The discovery that protein and nucleic acid demethylation is common opens up the
possibility of 'methylation cycles' of functional importance, including in the regulation of gene …

Recent studies demonstrated that histone methylation is not static but is dynamically
regulated by histone methyltransferases and the newly discovered histone demethylases …

The importance of histone methylation in gene regulation was suggested over 40 years ago.
Yet, the dynamic nature of this histone modification was recognized only recently, with the …

Histone modifications are thought to regulate chromatin structure, transcription and other
nuclear processes. Histone methylation was originally believed to be an irreversible …

The discovery of an increasing number of histone demethylases has highlighted the
dynamic nature of the regulation of histone methylation, a key chromatin modification that is …

Histone methylation has important roles in regulating transcription, genome integrity and
epigenetic inheritance. Historically, methylated histone arginine and lysine residues have …

Histone methylation plays fundamental roles in regulating chromatin‐based processes. With
the discovery of histone demethylases over a decade ago, it is now clear that histone …

Histone modifications serve as regulatory marks that are instrumental for the control of
transcription and chromatin architecture. Strict regulation of gene expression patterns is …

Heritable changes to the transcriptome that are independent to changes in the genome are
defined as epigenetics. DNA methylation and posttranslational modifications of histones …

Methylated lysines are important epigenetic marks. The enzymes involved in demethylation
have recently been discovered and found to be involved in cancer development and …