Histone modifications are thought to regulate chromatin structure, transcription and other
nuclear processes. Histone methylation was originally believed to be an irreversible …

The importance of histone methylation in gene regulation was suggested over 40 years ago.
Yet, the dynamic nature of this histone modification was recognized only recently, with the …

Histone methylation plays fundamental roles in regulating chromatin‐based processes. With
the discovery of histone demethylases over a decade ago, it is now clear that histone …

The enzymes catalyzing lysine and arginine methylation of histones are essential for
maintaining transcriptional programs and determining cell fate and identity. Until recently …

Epigenetic information refers to heritable changes in gene function that are stable between
cell divisions but which is not a result of changes in the DNA sequence. Part of the …

Histone modifications serve as regulatory marks that are instrumental for the control of
transcription and chromatin architecture. Strict regulation of gene expression patterns is …

Histone methylation has important roles in regulating transcription, genome integrity and
epigenetic inheritance. Historically, methylated histone arginine and lysine residues have …

Recent studies demonstrated that histone methylation is not static but is dynamically
regulated by histone methyltransferases and the newly discovered histone demethylases …

The discovery of an increasing number of histone demethylases has highlighted the
dynamic nature of the regulation of histone methylation, a key chromatin modification that is …

Histones are the major protein constituent of chromatin in the eukaryotic nucleus. These
proteins undergo a host of different post-translational modifications, including …