The epigenetic regulation of DNA-templated processes has been intensely studied over the
last 15 years. DNA methylation, histone modification, nucleosome remodeling, and RNA …

Epigenetics refers to heritable molecular determinants of phenotype independent of DNA
sequence. Epigenetic features include DNA methylation, histone modifications, non-coding …

Cancer was thought to be caused solely by genetic mutations in oncogenes and tumor
suppressor genes. In the last 35 years, however, epigenetic changes have been …

Abstract 'Epigenetics' is defined as the inheritable changes in gene expression with no
alterations in DNA sequences. Epigenetics is a rapidly expanding field, and the study of …

Alterations in the genome and the epigenome are common in most cancers. Changes in
epigenetic signatures, including aberrant DNA methylation and histone deacetylation, are …

Epigenetic mechanisms act to change the accessibility of chromatin to transcriptional
regulation locally and globally via modifications of the DNA and by modification or …

Epigenetic inactivation of genes that are crucial for the control of normal cell growth is a
hallmark of cancer cells. These epigenetic mechanisms include crosstalk between DNA …

Deregulation of gene expression is a hallmark of cancer. Although genetic lesions have
been the focus of cancer research for many years, it has become increasingly recognized …

Epigenetic mechanisms are essential for normal development and maintenance of tissue-
specific gene expression patterns in mammals. Disruption of epigenetic processes can lead …

Posttranslational modifications to histones affect chromatin structure and function resulting in
altered gene expression and changes in cell behavior. Aberrant gene expression and …