In 1957 Otto SCHAUMANN, one of the pionieers in pharmacological research on morphine
and the first to prepare synthetic opiates, presented a mono graph entitled" Morphin und …

Opioid receptors were originally conceived as specific sites in the CNS that form a crucial
link in the mechanism of pain perception and that fail to function in this respect when bound …

The opioid receptor ligands have their basis in more than 5000 years of medicinal use of
opium(from “opos,” the Greek word for juice), which is obtained by scoring the unripe seed …

The rapidly burgeoning research of the past two decades on agonist-antagonist analgesics
and opioid receptors makes this exhaustive review of opioid anal gesics particularly relevant …

The term opioid has come to represent the definition of any compound (exogenous or
endogenous) that interacts with opioid receptors. Other terms have been used in the past …

The early evolution of concepts of endogenous opioids and multiple opioid receptors had its
inception in a concerted program to develop safe, nonaddicting substitutes for opiates (see …

From our" bay view" in South San Francisco, we witnessed the recent developments in
opioid research and reflected on the many notable scientific revelations from prior meetings …

This brief review covers concepts in opioid pharmacology that were promoted during the
period leading up to the establishment of the International Narcotics Research Conference …

The enormous growth of opioid research in the last decade was initiated by the identification
of opiate receptors and the detection of their endogenous ligands, the opioid peptides or …

The field to be reviewed is now 16 years old and is based on knowledge dating back
centuries. It is therefore evident that an exhaustive review is impossible. The author plans to …