Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development

N Kushnir, SJ Streatfield, V Yusibov - Vaccine, 2012 - Elsevier
Virus-like particles (VLPs) are a class of subunit vaccines that differentiate themselves from
soluble recombinant antigens by stronger protective immunogenicity associated with the …

Virus-like particles in vaccine development

A Roldão, MCM Mellado, LR Castilho… - Expert review of …, 2010 - Taylor & Francis
Virus-like particles (VLPs) are multiprotein structures that mimic the organization and
conformation of authentic native viruses but lack the viral genome, potentially yielding safer …

Platforms, advances, and technical challenges in virus-like particles-based vaccines

R Gupta, K Arora, SS Roy, A Joseph… - Frontiers in …, 2023 - frontiersin.org
Viral infectious diseases threaten human health and global stability. Several vaccine
platforms, such as DNA, mRNA, recombinant viral vectors, and virus-like particle-based …

Virus-like particles: flexible platforms for vaccine development

B Chackerian - Expert review of vaccines, 2007 - Taylor & Francis
Virus-like particles (VLPs) consist of viral structural proteins that, when overexpressed,
spontaneously self-assemble into particles that are antigenically indistinguishable from …

Production of virus-like particles for vaccines

J Fuenmayor, F Gòdia, L Cervera - New biotechnology, 2017 - Elsevier
Virus-like particles (VLPs) are nanostructures that resemble the structures of viruses. They
are composed of one or more structural proteins that can be arranged in several layers and …

Virus-like particle vaccines: immunology and formulation for clinical translation

B Donaldson, Z Lateef, GF Walker… - Expert review of …, 2018 - Taylor & Francis
Introduction: Virus-like particle (VLP) vaccines face significant challenges in their translation
from laboratory models, to routine clinical administration. While some VLP vaccines thrive …

Virus-like particles: passport to immune recognition

EVL Grgacic, DA Anderson - Methods, 2006 - Elsevier
Virus-like particles (VLPs) are formed by the self-assembly of envelope and/or capsid
proteins from many viruses. In many cases such VLPs have structural characteristics and …

Virus‐like particles as powerful vaccination strategy against human viruses

I Hadj Hassine, M Ben M'hadheb… - Reviews in Medical …, 2024 - Wiley Online Library
Nowadays, viruses are not only seen as causative agents of viral infectious diseases but
also as valuable research materials for various biomedical purposes, including recombinant …

Virus-like particle vaccines and platforms for vaccine development

M Kheirvari, H Liu, E Tumban - Viruses, 2023 - mdpi.com
Virus-like particles (VLPs) have gained a lot of interest within the past two decades. The use
of VLP-based vaccines to protect against three infectious agents—hepatitis B virus, human …

Virus-like particles as immunogens

R Noad, P Roy - Trends in microbiology, 2003 - cell.com
Subunit vaccines based on recombinant proteins can suffer from poor immunogenicity
owing to incorrect folding of the target protein or poor presentation to the immune system …