The blood-brain barrier (BBB) separates the central nervous system (CNS) from the
peripheral tissues. However, this does not prevent hormones from entering the brain, but …

The blood–brain barrier (BBB) was first noted for its ability to prevent the unregulated
exchange of substances between the blood and the central nervous system (CNS). Over …

Proper functioning of the hypothalamic-pituitary-adrenal axis depends on the ability of
glucocorticoids (GCs), mainly cortisol in humans and corticosterone in rodents, to access …

Steroids have a wide spectrum of impact, serving as fundamental regulators of nearly every
physiological process within the human body. Therapeutic applications of steroids are …

The blood-brain barrier (BBB) mediates the communication between the periphery and the
central nervous system (CNS). Recently, CNS insulin resistance has been elucidated to play …

T HERE are at least two incentives for investigating the mechanisms of transport of peptides
through the brain capillary wall, ie. the blood-brain barrier (BBB). First, it is important to …

Barriers are the hallmark of a healthy physiology, blood-brain barrier (BBB) being a tough
nut to crack for most of the antigens and chemical substances. The presence of tight …

The concept of insulin resistance has been around since a few decades after the discovery
of insulin itself. To allude to the classic Charles Dicken's novel published 62 years before the …

An understanding of the mechanisms of transport of circulating nutrients and hormones
through the brain capillary wall, ie, the blood-brain barrier, is important because the …

BACKGROUND: Iodothyronines are charged amino acid derivatives that cannot passively
cross a phospholipid bilayer. Transport of thyroid hormones across plasma membranes is …