Presenilins (PSs) are the catalytic core of γ-secretase complex. However, the mechanism of
FAD-associated PS mutations in AD pathogenesis still remains elusive. Here we review the …

The presenilins are the catalytic subunit of the membrane-embedded tetrameric γ-secretase
protease complexes. More that 90 transmembrane proteins have been reported to be γ …

The presenilin (PS) genes harbor approximately 90% of the identified mutations linked to
familial forms of Alzheimer's disease, and the presenilin (PS) proteins are essential …

Presenilin, the catalytic member of the γ-secretase proteolytic complex, was discovered
through its roles in generating Alzheimer's-disease-associated amyloid-β peptides from the …

Mutations in PSEN1 and PSEN2 genes account for the majority of cases of early-onset
familial Alzheimer disease. Since the first prediction of a genetic link between PSEN1 and …

The presenilins in combination with other proteins generate different γ-secretases, which are
involved in the regulated intramembrane proteolysis of a variety of proteins. Understanding …

Mutations in the genes encoding presenilin 1 (PS1) and presenilin 2 (PS2) account for the
majority of the cases of familial early-onset Alzheimer's disease (FAD). Presenilins (PSs) …

Mutations in presenilins are responsible for the vast majority of early-onset familial
Alzheimer's disease cases. Full-length presenilin structure is composed of nine …

Inhibiting the production of amyloid-β by antagonising γ-secretase activity is currently being
pursued as a therapeutic strategy for Alzheimer's disease (AD). However, early pre-clinical …

Presenilins (PS) are the catalytic components of γ-secretase, an aspartyl protease that
regulates through proteolytic processing the function of multiple signaling proteins. Specially …