Peripheral T cell populations are maintained by production of naive T cells in the thymus,
clonal expansion of activated cells, cellular self-renewal (or homeostatic proliferation), and …

Immunology has traditionally been a qualitative science describing the cellular and
molecular components of the immune system and their functions. Only quite recently have …

Parallels between T cell kinetics in mice and men have fueled the idea that a young mouse
is a good model system for a young human, and an old mouse, for an elderly human. By …

The ability to measure, describe and interpret T cell kinetics is pivotal in understanding
normal lymphocyte homeostasis and diseases that affect T cell numbers. Following in vivo …

Our current view of T cell differentiation and population dynamics is assembled from pieces
of data obtained from separate experimental systems and is thus patchy. We reassessed …

Quantitative knowledge of the turnover of different leukocyte populations is a key to our
understanding of immune function in health and disease. Much progress has been made …

To study naive and memory CD8 T cell turnover, we performed BrdU incorporation
experiments in adult thymectomized C57BL/6 mice and analyzed data in a mathematical …

Measurement of T-cell kinetics: recent methodologic advances: Immunology Today Skip to
Main Content Advertisement Trends in Immunology This journal offers authors two options (open …

Homeostasis The sizes of T-and B-cell populations are maintained independently. A similar
number of mature B cells are found in normal, thymectomized and athymic mice, and in mice …

Quantitative understanding of the kinetics of lymphocyte proliferation and death upon
activation with an antigen is crucial for elucidating factors determining the magnitude …