Oligonucleotides containing an immune-stimulatory motif and an immune-regulatory motif
act as antagonists of Toll-like receptor (TLR) 7 and TLR9. In the present study, we designed …

Oligodeoxyribonucleotides containing unmethylated CpG motifs act as TLR9 agonists. In
this study, we evaluated oligonucleotides containing an unmethylated CpG motif in which …

Synthetic oligodeoxynucleotides containing unmethylated CpG motifs activate Toll-Like
Receptor 9 (TLR9). Our previous studies have shown the role of hydrogen-bond donor and …

Oligodeoxynucleotides (ODNs) containing unmethylated CpG dinucleotides act as agonists
of TLR9 and induce Th1-type immune responses. In the present study, we synthesized CpG …

Single-stranded RNAs act as ligands of Toll-like receptors (TLRs) 7 and 8 and induce
immune responses. In the present study, we have designed and synthesized …

Viral and synthetic single-stranded RNAs are the ligands for Toll-like receptors 7 and 8
(TLR7 and TLR8). We have reported a novel class of synthetic oligoribonucleotides, referred …

We previously reported a novel class of stabilized immune-modulatory RNA (SIMRA)
compounds that activates TLR8 or both TLR7 and TLR8 depending on the nucleotide …

The toll-like receptor (TLR) family is an evolutionarily conserved component of the innate
immune system, responsible for the early detection of foreign or endogenous threat signals …

Toll-like receptor (TLR) 7 and TLR8 are transmembrane receptors that recognize single-
stranded RNA. Activation of these receptors results in immune cell stimulation and …

Synthetic oligodeoxynucleotides containing unmethylated deoxycytidylyl‐deoxyguanosine
dinucleotide (CpG) motifs are able to stimulate potent immune responses through a …