There is increasing interest in discovering mechanisms that mediate the effects of childhood
stress on late-life disease morbidity and mortality. Previous studies have suggested one …

BACKGROUND: Psychological stress and trauma are risk factors for several medical and
psychiatric illnesses. Recent studies have implicated advanced cellular aging as a potential …

How can adverse experiences in early life, such as maltreatment, exert such powerful
negative effects on health decades later? The answer may lie in changes to DNA. New …

Telomeres are repetitive DNA sequences at the ends of chromatids that shorten following
each cell replication. Once telomeres reach a critical length, DNA defense mechanisms can …

The long-term sequelae of adverse early-life experiences have long been a focus in
psychiatry, with a historic neurobiological emphasis on physiological systems that are …

In the past decade, the growing field of telomere science has opened exciting new avenues
for understanding the cellular and molecular substrates of stress and stress-related aging …

BACKGROUND: To enhance the understanding of biological mechanisms connecting early
adversity and negative health, we examine the association between family interpersonal …

A growing literature suggests that exposure to adverse social conditions may accelerate
biological aging, offering one mechanism through which adversity may increase risk for age …

Stress over the lifespan is thought to promote accelerated aging and early disease.
Telomere length is a marker of cell aging that appears to be one mediator of this …

Objectives Chronic exposure to psychosocial stressors is related to worse somatic health.
This association applies both to stressors early in life, such as childhood adversities, and …