Understanding the substrate recognition mechanism of γ-secretase is a key step for
establishing substrate-specific inhibition of amyloid β-protein (Aβ) production. However, it is …

Abstract γ-secretase is an aspartyl protease that cleaves multiple substrates within their
transmembrane domains. γ-secretase processes the amyloid precursor protein (APP) to …

Abstract γ-Secretase generates the peptides of Alzheimer's disease, Aβ40 and Aβ42, by
cleaving the amyloid precursor protein within its transmembrane domain. γ-Secretase also …

γ-secretase is responsible for the proteolysis of amyloid precursor protein (APP) into short,
aggregation-prone amyloid-beta (Aβ) peptides, which are centrally implicated in the …

Abstract γ‐Secretase performs the final processing step in the generation of amyloid‐β (Aβ)
peptides, which are believed to be causative for Alzheimer's disease. Presenilins (PS) are …

Sequential proteolysis of the amyloid precursor protein (APP) by γ‐secretases generates
amyloid‐β (Aβ) peptides and defines the proportion of short‐to‐long Aβ peptides, which is …

γ-Secretase cleaves multiple substrates within the transmembrane domain that include the
amyloid precursor protein as well as the Notch family of receptors. These substrates are …

γ-Secretase is an intramembrane-cleaving protease responsible for the generation of
amyloid-β (Aβ) peptides. Recently, a series of compounds called γ-secretase modulators …

Processing of the amyloid precursor protein (APP) by β-and γ-secretases generates
pathogenic β-amyloid (Aβ) peptides associated with Alzheimer disease (AD), whereas …

γ-Secretase is responsible for the proteolysis of amyloid precursor protein (APP) into
amyloid-beta (Aβ) peptides, which are centrally implicated in the pathogenesis of …