Emerging roles for vasoactive peptides in diagnostic and therapeutic strategies against atherosclerotic cardiovascular diseases

T Watanabe, K Sato, F Itoh, Y Noguchi… - Current Protein and …, 2013 - ingentaconnect.com
Coronary artery disease (CAD) arising from atherosclerosis remains the most common
cause of death and morbidity worldwide, although its risk factors, such as hypertension …

Endogenous bioactive peptides as potential biomarkers for atherosclerotic coronary heart disease

T Watanabe, K Sato, F Itoh, K Wakabayashi, M Shichiri… - Sensors, 2012 - mdpi.com
Cardiovascular disease is the leading cause of death worldwide, with high medical costs
and rates of disability. It is therefore important to evaluate the use of cardiovascular …

Circulating levels of human salusin-β, a potent hemodynamic and atherogenesis regulator

K Fujimoto, A Hayashi, Y Kamata, A Ogawa… - PLoS …, 2013 - journals.plos.org
Using bioinformatics analysis, we previously identified salusin-β, an endogenous bioactive
peptide with diverse physiological activities. Salusin-β is abundantly expressed in the …

Salusins and adropin: new peptides potentially involved in lipid metabolism and atherosclerosis

L Niepolski, AE Grzegorzewska - Advances in medical sciences, 2016 - Elsevier
Dyslipidemia is one of the most potent risk factors for the development of atherosclerosis.
The high atherosclerotic risk in dyslipidemic patients is associated with endothelial …

[HTML][HTML] Use of salusin β for predicting atherosclerosis and components of the metabolic syndrome

A Janecka, J Stefanowicz - Advances in Clinical and …, 2024 - advances.umw.edu.pl
Salusin β is a bioactive peptide, detectable in many tissues and body fluids, first identified
nearly 20 years ago. Since then, many studies have been performed to define the role of …

Biosynthesis and secretion of salusin-α from human cells

K Sato, T Koyama, M Shichiri - Peptides, 2008 - Elsevier
Salusins originally identified using bioinformatics analyses have been shown to act on the
cardiovascular and endocrine systems. Although the hypotensive activity of salusin-α is …

The importance of circulating levels of salusin-α, salusin-β, and heregulin-β1 in atherosclerotic coronary arterial disease

A Arkan, P Atukeren, B Ikitimur, G Simsek, S Koksal… - Clinical …, 2021 - Elsevier
Objective The relationship between the severity of atherosclerotic coronary artery disease
(CAD) and circulating levels of salusin-α, salusin-β and heregulin-β1 has been investigated …

Salusins: potential use as a biomarker for atherosclerotic cardiovascular diseases

K Sato, R Watanabe, F Itoh, M Shichiri… - International journal …, 2013 - Wiley Online Library
Human salusin‐α and salusin‐β are related peptides produced from prosalusin. Bolus
injection of salusin‐β into rats induces more profound hypotension and bradycardia than …

Identification and quantification of plasma free salusin-β, an endogenous parasympathomimetic peptide

K Fujimoto, A Hayashi, Y Kodera, T Saito, T Toki… - Scientific reports, 2017 - nature.com
Salusin-β is an endogenous parasympathomimetic proatherosclerotic peptide. Salusin-β
was initially predicted from bioinformatic analyses and later immunologically detected in …

Salusins: advance in cardiovascular disease research

M Chen, B Deng, S Liu, Z Wang… - Journal of Pharmacy and …, 2023 - academic.oup.com
Salusins are discovered in 2003 and divided into salusin-α and salusin-β, which are
bioactive peptides with hemodynamic and mitotic activity and mainly distributed in plasma …