As a continuation of our research and with the aim of obtaining new agents against Chagas
disease, an extremely neglected disease which threatens 100 million people, eighteen new …

We report the synthesis and in vitro activity against Trypanosoma cruzi epimastigotes of 15
novel quinoxaline derivatives. Ten of the derivatives presented IC 50 values lower than the …

The discovery and development of essential drugs for Chagas disease is a major concern
worldwide. New substituted 1, 4-naphthoquinones were synthesized and tested against the …

More than 100 million people are at risk of contracting Chagas disease. It is estimated that in
2008, Chagas disease was responsible for the death of more than 10,000 people. Despite …

Chagas disease is one of the most important endemic diseases in Latin America, caused by
Trypanosoma cruzi. The drugs used for the treatment of this disease, nifurtimox and …

Quinoxalines belong to the N-containing heterocyclic compounds that stand out as having
promising biological activity due to their privileged scaffold. In this work, we report the …

New oxirane derivatives were synthesized using six naphthoquinones as the starting
materials. Our biological results showed that these oxiranes acted as trypanocidal agents …

Four new naphthofuranquinones, obtained from 2-hydroxy-3-allyl-naphthoquinone (1) and
nor-lapachol (2), have their structures established by physical and X-ray analysis and their …

Continuous efforts have been made to discover new drugs for the treatment of Chagas'
disease, human African trypanosomiasis, and leishmaniasis. We have previously reported …

For a fourth approach of quinoxaline N, N′-dioxides as anti-trypanosomatid agents against
T. cruzi and Leishmania, we found extremely active derivatives. The present study allows us …