Presenilin and signal peptide peptidase are multispanning intramembrane-cleaving
proteases with a conserved catalytic GxGD motif. Presenilin comprises the catalytic subunit …

The human genome encodes seven intramembrane-cleaving GXGD aspartic proteases.
These are the two presenilins that activate signaling molecules and are implicated in …

Highlights•A summary of recent structural advances on intramembrane proteases.•An
examination of the common and unique features of intramembrane proteases.•A discussion …

Presenilin and signal peptide peptidase (SPP) are intramembrane aspartyl proteases that
regulate important biological functions in eukaryotes. Mechanistic understanding of …

Background The GXGD-type diaspartyl intramembrane protease, presenilin, constitutes the
catalytic core of the γ-secretase multi-protein complex responsible for activating critical …

Intramembrane proteases catalyze the unusual cleavage of peptide bonds in the plane of
biological membranes. They are categorized according to their active site. The GxGD …

Alzheimer's disease is the most common form of neurodegenerative diseases in humans,
characterized by the progressive accumulation and aggregation of amyloid-β peptides (Aβ) …

Presenilin is a membrane-embedded intramembrane-cleaving protease with a conserved
catalytic G× GD motif. It is the catalytic subunit of γ-secretase, which plays critical roles in …

Presenilin is the catalytic component of the γ-secretase complex, a membrane-embedded
aspartyl protease that plays a central role in biology and in the pathogenesis of Alzheimer's …

Presenilin (PS) is the presumptive catalytic component of the intramembrane aspartyl
protease γ-secretase complex. Recently a family of presenilin homologs was identified. One …